Effects of Machado-Joseph Disease The most common symptoms of Machado-Joseph disease are: Tight muscles Poor walking pattern Muscle weakness in arms and legs Twitching of muscles Tingling/ pins and needles Slow to begin movement Trembling hands Poor balance Double or blurred vision Problems with memory Difficulty with speech and swallowing Frequency of urination Due to the signs and symptoms, Macho-Joseph disease is commonly mistaken for clumsiness, drunkenness or Parkinson?s disease. The symptoms get worse over time and can eventually lead to paralysis. It is essential that individuals with Machado-Joseph disease receive holistic multi-disciplinary management to ensure the symptoms have minimal effect on quality of life. Machado-Joseph Disease Diagnosis of Machado-Joseph Disease Types of Machado-Joseph Disease Effects of Machado-Joseph Disease Treatment for Machado-Joseph Disease Physiotherapy for Machado-Joseph Disease Why Manchester Neuro Physio To book an assessment or for more information please email office@manchesterneurophysio.co.uk call 0161 883 0066 . ← Previous Diagnosis of Machado Joseph disease Next → Error_log